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Infant feces-derived Lactobacillus gasseri FWJL-4 mitigates experimental necrotizing enterocolitis via acetate production.
Gut Microbes ( IF 12.2 ) Pub Date : 2024-12-08 , DOI: 10.1080/19490976.2024.2430541
Li-Long Pan,Yudong Sun,Xiaoliang Dong,Zhengnan Ren,Binbin Li,Ping Yang,Le Zhang,Jia Sun

Necrotizing enterocolitis (NEC) is a life-threatening disease in premature infants, characterized by high mortality. Recent studies increasingly highlight the role of gut dysbiosis in NEC pathogenesis. Although probiotics have shown some efficacy in preventing NEC, further research is needed to determine potential strains and approaches. In this study, we demonstrated that the novel probiotic strain Lactobacillus gasseri (L. gasseri) FWJL-4, isolated from the feces of healthy infants, significantly enhanced intestinal barrier function, providing substantial protection against NEC. This protective effect was attributed to elevated intestinal acetate levels. Notably, acetate supplementation alone was sufficient to mitigate NEC, mimicking the protective effects of L. gasseri FWJL-4. Mechanistically, we revealed that L. gasseri FWJL-4 inhibited necroptosis and preserved the number of the goblet cells and enterocytes through the production of the short-chain fatty acid acetate, via activation of the acetate receptors G protein-coupled receptor (GPR) 41 and GPR43. Our findings suggest that L. gasseri FWJL-4 enhances intestinal barrier function to protect against NEC, underscoring the potential of probiotic manipulation as a promising strategy for NEC prevention.

中文翻译:


婴儿粪便来源的加氏乳杆菌 FWJL-4 通过乙酸盐的产生减轻实验性坏死性小肠结肠炎。



坏死性小肠结肠炎 (NEC) 是一种危及早产儿生命的疾病,其特点是死亡率高。最近的研究越来越强调肠道菌群失调在 NEC 发病机制中的作用。尽管益生菌在预防 NEC 方面显示出一些疗效,但需要进一步研究来确定潜在的菌株和方法。在这项研究中,我们证明从健康婴儿粪便中分离的新型益生菌菌株加氏乳杆菌 (L. gasseri) FWJL-4 显着增强了肠道屏障功能,为预防 NEC 提供了实质性保护。这种保护作用归因于肠道乙酸盐水平升高。值得注意的是,单独补充醋酸盐就足以减轻 NEC,模仿加氏乳杆菌 FWJL-4 的保护作用。从机制上讲,我们揭示了 L. gasseri FWJL-4 通过激活乙酸受体 G 蛋白偶联受体 (GPR) 41 和 GPR43 通过产生短链脂肪酸乙酸酯来抑制坏死性凋亡并保留杯状细胞和肠上皮细胞的数量 43。我们的研究结果表明,L. gasseri FWJL-4 增强肠道屏障功能以预防 NEC,强调了益生菌操作作为预防 NEC 的有前途的策略的潜力。
更新日期:2024-12-08
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