OBJECTIVE This study investigates the efficacy and feasibility of electrical stimulation (E-Stim) on sensory fibers of the plantar region during hemodialysis sessions, aiming to improve mobility in patients with diabetes by providing a connection between E-Stim and enhanced mobility with minimal patient effort required. RESEARCH DESIGN AND METHODS Participants age ≥18 years with diabetes undergoing hemodialysis and able to walk at least 10 m with or without aid were recruited and divided into an intervention group receiving 1-h intradialytic E-Stim three times a week and a control group using an identical nonfunctional device for 12 weeks. Gait, physical activity, patient-reported outcomes, and the technology acceptance model were assessed to evaluate the intervention’s effectiveness and acceptance. RESULTS Out of 117 initial participants, 97 completed the study. Significant improvements were observed in the intervention group compared with the control group in gait performance (stride time at dual-task and fast walking), physical activity (stand to walk and sit to stand), quality of life, plantar numbness, and cognitive function after 12 weeks. The intervention group showed that magnitudes of improvement on gait performance and physical activity metrics were associated with enhancements in quality of life and cognitive function, respectively. The intervention group also reported higher usefulness and usage satisfaction, with a greater willingness to continue using E-Stim at home. CONCLUSIONS The 12-week intradialytic E-Stim intervention is a feasible and effective method to enhance gait performance, physical activity level, cognitive function, and other patient-reported outcomes in patients undergoing hemodialysis, representing a practical, low-risk therapy option for those unable to engage in traditional exercise programs.

中文翻译：

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糖尿病患者透析内足底电刺激的疗效和可行性：一项随机双盲对照试验


目的 本研究调查了血液透析期间电刺激 （E-Stim） 对足底区域感觉纤维的疗效和可行性，旨在通过在 E-Stim 和增强活动性之间建立联系来改善糖尿病患者的活动能力，同时需要最少的患者努力。研究设计和方法招募了年龄≥18 岁接受血液透析且能够在有或没有帮助的情况下行走至少 10 m 的参与者，并分为干预组，接受每周 3 次 1 小时的透析中 E-Stim，对照组使用相同的非功能设备 12 周。评估步态、身体活动、患者报告的结果和技术接受度模型，以评估干预的有效性和接受度。结果在 117 名初始参与者中，97 名完成了研究。与对照组相比，干预组在 12 周后步态表现 （双重任务和快速行走的步幅时间） 、身体活动 （站到走路和坐到站） 、生活质量、足底麻木和认知功能方面观察到显着改善。干预组显示，步态表现和身体活动指标的改善幅度分别与生活质量和认知功能的增强相关。干预组还报告了更高的有用性和使用满意度，更愿意在家中继续使用 E-Stim。 结论为期 12 周的透析中 E-Stim 干预是一种可行且有效的方法，可以提高接受血液透析的患者的步态表现、身体活动水平、认知功能和其他患者报告的结果，对于那些无法参与传统锻炼计划的人来说，这是一种实用、低风险的治疗选择。