OBJECTIVE We explored the potential value of continuous glucose monitoring (CGM) in early pregnancy in predicting gestational diabetes mellitus (GDM) and pregnancy outcomes. RESEARCH DESIGN AND METHODS The study recruited 103 multiethnic Asian pregnant women with overweight/obesity from a hospital-based, prospective cohort. All of them had worn blinded CGM devices in early pregnancy and underwent the universal GDM screening at 24–28 gestation weeks. Models were selected based on early pregnancy risk factors and CGM-derived parameters to compare their respective predictive values for GDM and pregnancy outcomes. RESULTS Eighteen GDM cases were ascertained. CGM-derived novel parameters demonstrated greater performance (e.g., area under the curve: 0.953 vs. 0.722) for predicting incident GDM compared with the model using traditional risks. Such novel CGM-derived parameters significantly differentiated primary cesarean and large-for-gestational age babies. CONCLUSIONS Our data suggest CGM's potential clinical utility in the first trimester for predicting GDM and adverse pregnancy outcomes, particularly in overweight or obese individuals.

中文翻译：

---

利用连续血糖监测及早检测亚洲人群的妊娠糖尿病和妊娠结局


目的 我们探讨了妊娠早期连续血糖监测 （CGM） 在预测妊娠糖尿病 （GDM） 和妊娠结局方面的潜在价值。研究设计和方法 该研究从以医院为基础的前瞻性队列中招募了 103 名超重/肥胖的多种族亚裔孕妇。他们都在怀孕早期佩戴了盲法 CGM 装置，并在妊娠 24-28 周接受了普遍的 GDM 筛查。根据早期妊娠危险因素和 CGM 衍生参数选择模型，以比较它们各自对 GDM 和妊娠结局的预测价值。结果 确定了 18 例 GDM 病例。与使用传统风险的模型相比，CGM 衍生的新参数在预测事件 GDM 方面表现出更好的性能 （例如，曲线下面积：0.953 vs. 0.722）。这种新颖的 CGM 衍生参数显著区分了初次剖宫产和大于胎龄儿。结论 我们的数据表明 CGM 在妊娠早期预测 GDM 和不良妊娠结局的潜在临床效用，尤其是在超重或肥胖个体中。