OBJECTIVE To evaluate the clinical and laboratory outcomes of patients with type 2 diabetes by comparing the no reuse or reuse of syringes and needles for insulin injection. RESEARCH DESIGN AND METHODS Adults with type 2 diabetes who had reused syringes and needles at least three times were randomly instructed either to not reuse or to reuse insulin syringes and needles five times. The primary outcomes assessed were glycemic control, pain scores, and skin complications (ecchymosis, lipohypertrophy, nodules, infection) at baseline and 4, 8, and 12 weeks after the intervention. Secondary outcomes included treatment adherence, quality of life, microbiological contamination of syringes and needles, needle quality, and insulin injection technique. RESULTS Among the 71 participants (mean ± SD age 59.7 ± 8.8 years), 59% were women with a median duration of diabetes of 18 years (interquartile range 10–25 years) and a mean BMI of 31.7 ± 6.7 kg/m2. The group that reused syringes and needles experienced an increase in lipohypertrophy/nodules (0.16 ± 0.08, P = 0.040) but did not experience worsening pain or glycemic control, even when the syringes and needles were inserted into the skin with great effort. There was no difference in the total number of skin complications, quality of life, or microbiological contamination. Both groups improved treatment adherence, with a greater increase in the reuse group. CONCLUSIONS The reuse of syringes and needles is associated with a modest increase in lipohypertrophy/nodules but does not have a short-term impact on glycemic control in patients with type 2 diabetes.

中文翻译：

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注射器和针头重复使用对 2 型糖尿病患者临床结果的影响：一项为期 12 周的随机临床试验


目的 通过比较胰岛素注射注射器和针头不重复使用或重复使用来评估 2 型糖尿病患者的临床和实验室结局。研究设计和方法 重复使用注射器和针头至少 3 次的 2 型糖尿病成人患者被随机指示不重复使用或重复使用胰岛素注射器和针头 5 次。评估的主要结局是基线和干预后 4 、 8 和 12 周的血糖控制、疼痛评分和皮肤并发症 （瘀斑、脂肪肥大、结节、感染）。次要结局包括治疗依从性、生活质量、注射器和针头的微生物污染、针头质量和胰岛素注射技术。结果 在 71 名参与者中 （SD 平均年龄 59.7 ± 8.8 岁） ± 59% 是糖尿病中位病程为 18 岁 （四分位距 10-25 岁） 且平均 BMI 为 31.7 ± 6.7 kg/m2 的女性。重复使用注射器和针头的组脂肪肥大/结节增加 （0.16 ± 0.08，P = 0.040），但没有出现疼痛恶化或血糖控制，即使注射器和针头费力插入皮肤。皮肤并发症总数、生活质量或微生物污染没有差异。两组都提高了治疗依从性，重复使用组的增加更大。结论 注射器和针头的重复使用与脂肪肥大/结节的适度增加有关，但对 2 型糖尿病患者的血糖控制没有短期影响。