OBJECTIVE To compare the prevalence of parental diabetes between children with and without type 1 diabetes (T1D), and to compare clinical characteristics at diagnosis of T1D in children with, versus without, a family history of diabetes. RESEARCH DESIGN AND METHODS Parental diabetes among children with T1D was compared with a general population cohort. Clinical characteristics were compared by family history of diabetes in parents and grandparents of 3,603 children with T1D using relative risk (RR) and ANOVA. RESULTS Children with T1D more often had parents with type 2 diabetes (T2D) (RR 1.88; P < 0.001) than did children without diabetes. Children with T1D and a family history of T2D were more likely to be overweight or obese (P = 0.002). CONCLUSIONS A family history of T2D and being overweight may contribute to increased risk of T1D.

中文翻译：

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诊断为 1 型糖尿病的儿童糖尿病家族史和临床特征——一项瑞典基于人群的研究


目的 比较 1 型糖尿病 （T1D） 患儿和无 1 型糖尿病 （T1D） 患儿的父母糖尿病患病率，并比较有糖尿病家族史与无糖尿病家族史的儿童诊断 T1D 的临床特征。研究设计和方法 将 T1D 儿童的父母糖尿病与一般人群队列进行比较。使用相对风险 （RR） 和方差分析，通过 3,603 名 T1D 儿童的父母和祖父母的糖尿病家族史比较临床特征。结果 T1D 患儿的父母更常患有 2 型糖尿病 （T2D） （RR 1.88;P < 0.001） 比没有糖尿病的儿童。患有 T1D 和 T2D 家族史的儿童更有可能超重或肥胖 （P = 0.002）。结论 T2D 家族史和超重可能导致 T1D 风险增加。