BACKGROUND Multidomain lifestyle interventions may have the potential to slow biological aging as captured by deficit accumulation frailty indices. We describe the distribution and composition of the 49-component frailty index (FI) developed by the U.S. POINTER clinical trial team of investigators and assess its cross-sectional associations with sociodemographic factors and markers chosen to be representative of behaviors targeted by the trial's multidomain interventions. METHODS We draw baseline data from the 2111 volunteers enrolled in U.S. POINTER who were ages 60-79 years and at increased risk for cognitive decline. Frailty components were grouped into nine domains. Associations that FI scores and their domains had with behavioral markers were described with correlations and canonical correlation. RESULTS The 25th, 50th, and 75th percentiles of the frailty index score distribution were 0.153, 0.189, and 0.235. Higher frailty scores tended to occur among individuals who were older, male, and living in areas of greater deprivation (all p<0.001). They were also associated with poorer self-reported diet, less physical activity, and higher Framingham risk scores (all p<0.001). Associations were diffusely distributed among the frailty component domains, indicating that no individual domain was dominating associations. CONCLUSIONS The U.S. POINTER deficit accumulation frailty index had expected relationships with sociodemographic factors and sensitivity to the behaviors targeted by the trial's interventions. Our analysis supports its use as a secondary outcome to assess whether the multidomain interventions differentially impact an established marker of biological aging.

中文翻译：

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美国 POINTER 试验中缺陷积累虚弱与生活方式基线标志物之间的关联。


背景 多领域生活方式干预可能有可能减缓缺陷积累虚弱指数所捕捉的生物衰老。我们描述了由 U.S. POINTER 临床试验研究者团队开发的 49 个组成部分的衰弱指数 （FI） 的分布和组成，并评估其与社会人口学因素和选择代表试验多领域干预所针对行为的标志物的横断面关联。方法 我们从 2111 名参加 U.S. POINTER 的志愿者中提取基线数据，这些志愿者年龄在 60-79 岁之间，认知能力下降的风险增加。衰弱成分分为 9 个领域。FI 分数及其领域与行为标志物的关联用相关性和典型相关性来描述。结果 衰弱指数评分分布的第 25 、 50 和第 75 个百分位数分别为 0.153 、 0.189 和 0.235。较高的虚弱评分往往发生在老年人、男性和生活在更贫困地区的个体中 （均 p<0.001）。他们还与自我报告的饮食较差、体力活动较少和 Framingham 风险评分较高有关 （均 p<0.001）。关联在脆弱成分域之间分散分布，表明没有单个域主导关联。结论 美国指针缺陷积累虚弱指数与社会人口学因素和对试验干预所针对的行为的敏感性具有预期关系。我们的分析支持将其用作次要结果，以评估多领域干预是否对已建立的生物衰老标志物产生差异影响。