Obesity accelerates the onset and progression of age-related conditions. In preclinical models, obesity drives cellular senescence, a cell fate that compromises tissue health and function, in part through a robust and diverse secretome. In humans, components of the secretome have been used as senescence biomarkers that are predictive of age-related disease, disability, and mortality. Here, using biospecimens and clinical data from two large and independent cohorts of older adults, we tested the hypothesis that the circulating concentrations of senescence biomarkers are influenced by body mass index (BMI). After adjusting for age, sex, and race, we observed significant increases in activin A, Fas, MDC, PAI1, PARC, TNFR1, and VEGFA, and a significant decrease in RAGE, from normal weight, to overweight, to obesity BMI categories by linear regression in both cohorts (all p < 0.05). These results highlight the influence of BMI on circulating concentrations of senescence biomarkers.

中文翻译：

---

体重指数对老年人细胞衰老生物标志物的影响


肥胖会加速与年龄相关的疾病的发作和发展。在临床前模型中，肥胖会驱动细胞衰老，这种细胞命运会损害组织健康和功能，部分原因是分泌组强大而多样。在人类中，分泌组的成分已被用作衰老生物标志物，可预测与年龄相关的疾病、残疾和死亡率。在这里，使用来自两个大型独立老年人队列的生物样本和临床数据，我们检验了衰老生物标志物的循环浓度受体重指数 （BMI） 影响的假设。在调整了年龄、性别和种族后，我们观察到激活素 A、Fas、MDC、PAI1、PARC、TNFR1 和 VEGFA 显着增加，并且 RAGE 显着降低，从正常体重到超重，再到肥胖 BMI 类别在两个队列中 （均 p < 0.05）。这些结果突出了 BMI 对衰老生物标志物循环浓度的影响。