It is becoming highly accepted that aging, age-related diseases, and geriatric healthcare can move forward if reductionist research is complemented by integrative research uniting knowledge on specific aging mechanisms, multiple biomedical, social, psychological, lifestyle, and environmental factors and their interactions. In this special issue, we present exciting papers that illustrate how complexity science theory and practice can be applied to aging research and provide a better understanding and quantification of healthy aging and vulnerability to disease. Recent insights on biomarkers, clocks of aging, frailty, and resilience are covered and studied in interaction with a dynamic multiscale perspective. The editorial and closing viewpoint guide you through basic principles of gerontological complexity science and shed light on new research horizons, including innovative systems-based interventions.

中文翻译：

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复杂系统视角阐明衰老的力量


人们普遍认为，如果还原论研究得到结合特定衰老机制、多种生物医学、社会、心理、生活方式和环境因素及其相互作用的知识的综合研究的补充，老龄化、与年龄相关的疾病和老年保健就可以向前发展。在本期特刊中，我们提出了令人兴奋的论文，阐述了复杂性科学理论和实践如何应用于衰老研究，并提供对健康衰老和疾病脆弱性的更好理解和量化。通过与动态多尺度视角的相互作用，涵盖和研究了关于生物标志物、衰老时钟、虚弱和恢复力的最新见解。社论和结束语的观点将引导您了解老年学复杂性科学的基本原理，并阐明新的研究视野，包括基于系统的创新干预措施。