Diabetic myopathy is characterized by the loss of skeletal muscle mass and function. NOD-like receptor family pyrin domain containing 3 (NLRP3)–mediated pyroptosis is a type of proinflammatory cell death, which can exacerbate significant muscle cell loss and adverse remodelling. The stimulator of interferon genes (STING) is an essential molecule involved in the regulation of inflammation and immune responses across various diseases. The regulatory mechanism by which STING affects muscle pyroptosis in diabetic myopathy remains unclear.

中文翻译：

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干扰素基因缺乏的刺激剂通过抑制 NLRP3 介导的细胞焦亡来减轻糖尿病肌病


糖尿病肌病的特征是骨骼肌质量和功能丧失。NOD 样受体家族含 3 （NLRP3） 介导的细胞焦亡是一种促炎细胞死亡，可加剧严重的肌肉细胞丢失和不良重塑。干扰素基因刺激物 （STING） 是一种重要分子，参与各种疾病的炎症和免疫反应的调节。STING 影响糖尿病肌病肌肉焦亡的调节机制尚不清楚。