S-pindolol has metabolic effects of potential benefit in cancer cachexia: reduced catabolism through nonselective β-blockade; increased anabolism through partial β2 receptor agonism; and increased appetite and reduced fatigue through central 5-hydroxytryptamine/serotonin receptor activity. A Phase 2a clinical trial demonstrated that S-pindolol can reverse weight loss and improve fat-free mass in patients with cancer-related weight loss. A comparative phase I bioavailability study of S-pindolol and racemic pindolol was performed to support the development of S-pindolol in cancer cachexia.

中文翻译：

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ACM-001.1（S-苯甲酸吲哚洛尔）在健康志愿者中的药代动力学、药效学和生物利用度


S-吲哚洛尔在癌症恶病质中具有潜在益处的代谢作用：通过非选择性 β 阻断减少分解代谢;通过部分 β 2 受体激动作用增加合成代谢;以及通过中枢 5-羟色胺/血清素受体活性增加食欲和减轻疲劳。一项 2a 期临床试验表明，S-吲哚洛尔可以逆转癌症相关体重减轻患者的体重减轻并改善无脂肪质量。进行了 S-吲哚洛尔和外消旋吲哚洛尔的 I 期生物利用度比较研究，以支持 S-吲哚洛尔在癌症恶病质中的发展。