Astronauts in Earth's orbit experience microgravity, resulting in a decline of skeletal muscle mass and function. On Earth, models simulating microgravity have shown that the extent of the loss in muscle force is greater than the loss in muscle mass. The reasons behind this disproportionate loss of muscle force are still poorly understood. In the present study, we hypothesize that alongside the loss in skeletal muscle mass, modifications in the expression profile of genes encoding critical determinants of resting membrane potential, excitation-contraction coupling and Ca²⁺ handling contribute to the decline in skeletal muscle force.

中文翻译：

---

人体干浸 5 天后骨骼肌力损失的分子决定因素


地球轨道上的宇航员会受到微重力的影响，导致骨骼肌质量和功能下降。在地球上，模拟微重力的模型表明，肌肉力量的损失程度大于肌肉质量的损失。这种不成比例的肌肉力量损失背后的原因仍然知之甚少。在本研究中，我们假设除了骨骼肌质量的损失外，编码静息膜电位关键决定因素、兴奋-收缩耦合和 Ca²⁺ 处理的基因表达谱的改变也会导致骨骼肌力量的下降。