Kidney organoids represent a tangible in vitro system in which to model disease, identify novel therapeutics, and investigate cellular and physiological mechanisms. However, their relative immaturity and insufficient endowment of critical cell types limits their translational efficacy. Addressing a number of these shortcomings, Maggiore et al. present a novel genetically inducible vascularized kidney organoid model. Organoids develop a robust endothelial network with kidney-specific features that enhances podocyte maturity and supports the generation of functional renin+ cells.

中文翻译：

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通过诱导型血管化提高肾脏类器官成熟度：体外建模的又一步


肾脏类器官代表了一个有形 的体外系统，用于模拟疾病、确定新疗法以及研究细胞和生理机制。然而，它们的相对不成熟和关键细胞类型的禀赋不足限制了它们的转化功效。针对其中的一些缺点，Maggiore 等 人提出了一种新的遗传诱导血管化肾类器官模型。类器官发育出具有肾脏特异性特征的强大内皮网络，可增强足细胞成熟并支持功能性肾素 + 细胞的产生。