Chronic kidney disease (CKD) is associated with an increased risk of cognitive impairment. Patients with CKD display an increased permeability of the blood-brain barrier. Zimmermann et al. highlighted the implication of potassium efflux in the microglia and its activation, the activation of the interleukin-1b/interleukin-1R pathway, linked to blood-brain barrier permeability and cognitive impairment in CKD. Along with uremic toxicity, this study provides new solid insights about pathophysiological mechanisms of cognitive impairment in CKD, and potential therapeutic targets.

中文翻译：

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对慢性肾病认知障碍潜在机制的新见解。


慢性肾脏病 （CKD） 与认知障碍风险增加有关。CKD 患者表现出血脑屏障通透性增加。Zimmermann 等人强调了钾外排在小胶质细胞中及其激活的影响，白细胞介素-1b/白细胞介素-1R 通路的激活，与 CKD 的血脑屏障通透性和认知障碍有关。除了尿毒症毒性，本研究还提供了关于 CKD 认知障碍的病理生理机制和潜在治疗靶点的新坚实见解。