Cholesterol crystal embolism (CCE) is a complication of atherosclerosis and can cause microvascular obstruction in multiple organs. Because the consequences may be fatal, and there is no specific treatment, it is crucial to understand the mechanisms and identify treatment strategies. In this issue, Zhao et al., using a mouse model of kidney CCE, demonstrated that inhibition of C5a/C5aR prevented and resolved CCE-induced renal thrombosis and angiopathy. Although these findings must be extended to human condition, they offer hope for management of CCE syndrome.

中文翻译：

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看着胆固醇水晶球：补体是答案吗？


胆固醇晶体栓塞 （CCE） 是动脉粥样硬化的一种并发症，可导致多个器官出现微血管阻塞。因为后果可能是致命的，而且没有特定的治疗方法，所以了解机制和确定治疗策略至关重要。在本期中，Zhao 等人使用肾脏 CCE 的小鼠模型证明，抑制 C5a/C5aR 可预防和解决 CCE 诱导的肾血栓形成和血管病。尽管这些发现必须扩展到人类状况，但它们为 CCE 综合征的管理提供了希望。