Recent reports have described acute kidney injury in otherwise healthy individuals after exposure to hair-straightening products. In this issue, Robert et al. help elucidate the underlying mechanisms in a murine model that replicates the human pathology. Cutaneous absorption of glyoxylic acid from hair-straightening products and its subsequent conversion to oxalate are identified as crucial steps in the development of oxalate nephropathy. This newly described "skin-kidney" axis expands our understanding of oxalate metabolism, calls for additional studies to explore susceptibility to acute kidney injury following cutaneous glyoxylate exposure, and warrants vigilance around the use of these products.

中文翻译：

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与含乙醛酸盐的直发产品相关的草酸盐肾病：呼吁谨慎。


最近的报告描述了其他方面健康的个体在接触直发产品后会出现急性肾损伤。在本期中，Robert 等人帮助阐明了复制人类病理学的小鼠模型的潜在机制。皮肤对直发产品中乙醛酸的吸收及其随后转化为草酸盐被认为是草酸盐肾病发展的关键步骤。这种新描述的“皮肤-肾脏”轴扩展了我们对草酸盐代谢的理解，需要进行更多研究以探索皮肤乙醛酸盐暴露后急性肾损伤的易感性，并保证对这些产品的使用保持警惕。