In a recent cryo-EM study published in Nature, Bayly-Jones and co-workers have provided detailed molecular insights into the dimerization and cholesterol binding of the orphan G protein-coupled receptor GPR155, its potential involvement in gut microbiota-derived tryptophan metabolite interactions, and intracellular signaling pathways.¹ GPR155, a lysosomal protein with a unique 17-transmembrane helix domain structure, integrates auxin transporter and G protein-coupled receptor-like features, playing a key role in lysosomal cholesterol sensing and mTORC1 signaling.

中文翻译：

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超越经典的 GPCR：揭示 GPR155 在胆固醇感应和信号传导中的作用

在最近发表在《自然》杂志上的一项冷冻电镜研究中，Bayly-Jones 及其同事对孤儿 G 蛋白偶联受体 GPR155 的二聚化和胆固醇结合、其可能参与肠道微生物群衍生的色氨酸代谢物相互作用以及细胞内信号通路提供了详细的分子见解。¹ GPR155 是一种具有独特 17 次跨膜螺旋结构域结构的溶酶体蛋白，整合了生长素转运蛋白和 G 蛋白偶联受体样特征，在溶酶体胆固醇感应和 mTORC1 信号传导中发挥关键作用。