A recent publication in Nature¹ identified early intermittent hyperlipidemia as a new determinant of atherosclerosis driving an altered phenotype of arterial-resident macrophages with defects in autophagy- and efferocytosis-related pathways. These intriguing findings infer the need for preemptive control of cholesterol already at younger age to prevent and limit atherosclerosis.

中文翻译：

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早期间歇性胆固醇暴露会加速动脉粥样硬化：需要先发制人的振荡放大器

最近发表在 Nature¹ 上的一篇文章确定早期间歇性高脂血症是动脉粥样硬化的新决定因素，导致动脉驻留巨噬细胞表型改变，自噬和泡泡细胞增多相关途径存在缺陷。这些有趣的发现推断出需要在年轻时就先发制人地控制胆固醇，以预防和限制动脉粥样硬化。