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Post-fast refeeding: rise of intestinal stemness and mutagen-induced cancer risk through polyamine metabolism
Signal Transduction and Targeted Therapy ( IF 40.8 ) Pub Date : 2024-11-11 , DOI: 10.1038/s41392-024-02038-1 Sarah Brunner, Klaus-Peter Janssen, Josef Ecker
中文翻译:
禁食后再喂养:肠道干性增加和诱变剂通过多胺代谢诱导的癌症风险
更新日期:2024-11-12
Signal Transduction and Targeted Therapy ( IF 40.8 ) Pub Date : 2024-11-11 , DOI: 10.1038/s41392-024-02038-1 Sarah Brunner, Klaus-Peter Janssen, Josef Ecker
An increased intestinal stem cell activity following post fast-refeeding is beneficial for regeneration, but too much could increase the risk for cancer in mice, as reported in a recent study by Imada and colleagues published in Nature.1 In consequence, fast-refeeding cycles should be thoroughly planned, when dietary strategies are considered for regeneration to minimize cancer risks.
中文翻译:
禁食后再喂养:肠道干性增加和诱变剂通过多胺代谢诱导的癌症风险
正如 Imada 及其同事最近发表在《自然》杂志上的一项研究中所报道的那样,禁食后肠道干细胞活性增加后肠道干细胞活性增加有利于再生,但过多会增加小鼠患癌症的风险。1 因此,当考虑饮食策略进行再生以最大限度地降低癌症风险时,应彻底规划快速再喂养周期。