In a recent Cell study, Xie et al.¹ introduce a novel mass spectrometry-based methodology for the sensitive detection and enrichment of native sialic acid-containing glycoRNA on cell surfaces. This work represents a significant advancement in the emerging field of glycoRNA biology. The authors linked acp³U, a modified uridine which was first described five decades ago, with RNA glycosylation in mammalian cells.

中文翻译：

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解开 RNA 密码：尿苷 RNA 修饰驱动 glycoRNA 生物发生

在最近的一项细胞研究中，Xie 等^{人1 介绍了}一种基于质谱的新型方法，用于灵敏检测和富集细胞表面含天然唾液酸的 glycoRNA。这项工作代表了 glycoRNA 生物学新兴领域的重大进步。作者将 acp³U（一种五十年前首次被描述的修饰尿苷）与哺乳动物细胞中的 RNA 糖基化联系起来。