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Concurrently depleting regulatory T cells and activating cytotoxic T cells in tumours
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2024-12-20 , DOI: 10.1038/s41551-024-01305-4
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2024-12-20 , DOI: 10.1038/s41551-024-01305-4
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An anti-4-1BB antibody fused to interleukin-15 via a peptide that is sensitive to tumour proteases concurrently depletes regulatory T cells and expands cytotoxic T cells in the tumour microenvironment. This fusion protein augments tumour inhibition without increasing systemic toxicity.
更新日期：2024-12-20
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