large diverse patient population in the United States. Methods: A cross-sectional study (2010-2021) was performed within an integrated health system in patients (age ≥18yrs) with biopsy-proven FSGS. Among biopsies with FSGS as the first diagnosis on pathology report, chart reviews were performed to determine primary FSGS, defined as podocyte foot process effacement ≥80% on electron microscopy. The proportion of patients with primary FSGS and annual incidence rates (per 100,000 patient-years) were calculated. Standardized incidence rates were determined by age, sex, and race and ethnicity based on US population structure of the five-year (2018-2022) American Community Survey estimates. Results: We identified 3,838 patients with FSGS reported on biopsy. Among 1,502 with FSGS as the principal diagnosis, 637 met criteria for primary FSGS (mean [SD] age 55.5 years [17.9], 56.5% male, 35.6% Hispanic, 28.7% White, 17.9% Asian/Pacific Islander, and 16.0% Black). The mean standardized incidence rate [CI] of primary FSGS was 1.7 [0.9, 2.5] per 100,000 patient-years during the study period. The standardized annual incidence rates ranged from 1.3 – 2.4 per 100,000 patient-years. Incidence rates (per 100,000 patient-years) were highest among Black (3.2), Asian (2.7), and Pacific Islander (2.8) patients. Conclusion: Primary FSGS accounted for 16.6% of biopsy-proven FSGS. Primary FSGS is a likely a rare disease with incidence highest among Black, Asian, and Pacific Islander people. More precise identification of primary FSGS may facilitate work to improve understanding of this glomerulopathy and improve kidney outcomes. Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Nephrology...

中文翻译：

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2010-2021 年种族和民族多元化成年患者群体中原发性局灶节段性肾小球硬化 （FSGS） 的发病率和比例


美国庞大而多样化的患者群体。方法： 在综合卫生系统内对经活检证实的 FSGS 患者 （≥18 岁） 进行了一项横断面研究 （2010-2021）。在以 FSGS 作为病理报告首诊诊断的活检中，进行图表审查以确定原发性 FSGS，定义为足细胞足突消失 ≥80% 在电子显微镜下。计算原发性 FSGS 患者的比例和年发病率 （每 100,000 患者年）。标准化发病率是根据五年 （2018-2022） 美国社区调查估计的美国人口结构，按年龄、性别、种族和民族确定的。结果： 我们确定了 3,838 例活检报告的 FSGS 患者。在 1,502 例以 FSGS 为主要诊断的病例中，637 例符合原发性 FSGS 的标准（平均 [SD] 年龄 55.5 岁 [17.9]，56.5% 男性，35.6% 西班牙裔，28.7% 白人，17.9% 亚裔/太平洋岛民和 16.0% 黑人）。在研究期间，原发性 FSGS 的平均标准化发病率 [CI] 为 1.7 [0.9， 2.5] /100,000 患者年。标准化年发病率为每 100,000 患者年 1.3 – 2.4 例。黑人 （3.2） 、亚裔 （2.7） 和太平洋岛民 （2.8） 患者的发病率 （每 100,000 患者年） 最高。结论： 原发性 FSGS 占活检证实的 FSGS 的 16.6%。原发性 FSGS 可能是一种罕见疾病，在黑人、亚洲和太平洋岛民中发病率最高。更精确地识别原发性 FSGS 可能有助于提高对这种肾小球病的理解并改善肾脏结局的工作。版权所有 © 2024 作者。由 Wolters Kluwer Health， Inc. 代表美国肾脏病学会出版...