he effect of donation on future pregnancies and of pregnancy-related complications on postdonation outcomes. In February 2023, the American Society of Transplantation Women's Health Community of Practice held a virtual Controversies Conference on reproductive health, contraception, and pregnancy after transplantation and living donation. Experts in the field presented the available data. Smaller breakout sessions were created to discuss findings, identify knowledge gaps, and develop recommendations. We present the conference findings related to living donation. The evidence reviewed shows that gestational hypertension and gestational diabetes mellitus before kidney donation have been associated with an increased risk of developing postdonation hypertension and diabetes mellitus, respectively, without increasing the risk of developing an eGFR <45 ml/min after donation. The risk of preeclampsia in living kidney donors increases to 4%–10%, and low-dose aspirin may help reduce that risk. Little is known about the financial burden for living donors who become pregnant, their risk of postpartum depression, or the optimal time between donation and conception. The data on living liver donors are even scarcer. The creation of a registry of donor candidates may help answer many of these questions and, in turn, educate prospective donors so that they can make an informed choice....

中文翻译：

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活体捐献和妊娠相关并发症：改进风险评估的证据状况和行动呼吁


捐献对未来妊娠的影响以及妊娠相关并发症对捐献后结局的影响。2023 年 2 月，美国移植学会妇女健康实践社区举行了一次关于生殖健康、避孕以及移植后怀孕和活体捐献的虚拟争议会议。该领域的专家介绍了可用数据。创建了较小的分组会议来讨论发现、识别知识差距并提出建议。我们介绍了与活体捐献相关的会议结果。回顾的证据表明，肾脏捐献前妊娠高血压和妊娠糖尿病分别与捐献后高血压和糖尿病的风险增加有关，而没有增加捐献后发生 eGFR <45 ml/min 的风险。活体肾脏供体患子痫前期的风险增加到 4%-10%，低剂量阿司匹林可能有助于降低这种风险。人们对怀孕的活体捐献者的经济负担、他们患产后抑郁症的风险或捐献和受孕之间的最佳时间知之甚少。关于活体肝脏供体的数据甚至更为稀缺。创建捐赠者候选人登记册可能有助于回答其中的许多问题，反过来，教育潜在的捐赠者，以便他们能够做出明智的选择。