ransfer to HD. Methods: We analyzed a multicenter, international cohort of PD patients enrolled in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) from 2014-2022. Pruritus was assessed at entry into PDOPPS with a single-question Likert Scale capturing the extent to which patients were bothered by itch ranging from 1: Not at all, to 5: Extremely. The KDQOL-36 and the Centre for Epidemiological Studies Depression Scale assessed various PROs. Moderate to extreme pruritus was defined as a Likert scale score ≥3. The associations of pruritus with PROs were assessed using linear/logistic regression where appropriate. Death or HD transfer was assessed using multivariable Cox regression models. Results: Overall, 5535 patients from seven countries were included; 43% had moderate to extreme pruritus which was highest in Thailand (50%) and lowest in the United States (33%). The adjusted odds ratios (aOR) of moderate to extreme pruritus were higher for diabetes, low albumin, and elevated phosphorus but lower for residual urine volume (aOR= 0.98 per 200 ml increase in 24-hour urine volume, 95% confidence interval [CI]; 0.96-1.00, P=0.05). Patients with extreme pruritus had the lowest mental and physical health component scores and a higher burden of other PROs including restless legs and disturbed sleep. Overall, 899 patients died and 1221 transferred to HD. Patients with moderate to extreme pruritus were at higher adjusted risk for death or HD transfer (adjusted hazard ratio [aHR] 1.12, 95% CI 1.02-1.23, P=0.02) with similar point estimates for each subcomponent of the composite outcome. Conclusions: Pruritus is highly prevalent in PD and associated with poor health outcomes. Efforts to better identify and manage pruritus should be considered in this population. Copyright © 2024 by the American Society of Nephrology...

中文翻译：

---

慢性肾脏病相关瘙痒的患病率和结局：PDOPPS 的国际结果


方法： 我们分析了 2014-2022 年参加腹膜透析结果和实践模式研究 （PDOPPS） 的多中心、国际 PD 患者队列。在进入 PDOPPS 时，使用单问题李克特量表评估瘙痒，该量表捕捉了患者受瘙痒困扰的程度，范围从 1：完全没有，到 5：极度。KDQOL-36 和流行病学研究中心抑郁量表评估了各种 PRO。中度至极度瘙痒定义为李克特量表评分 ≥3。在适当的情况下使用线性/logistic 回归评估瘙痒与 PRO 的相关性。使用多变量 Cox 回归模型评估死亡或 HD 转移。结果： 共纳入来自 7 个国家的 5535 例患者;43% 的患者患有中度至极度瘙痒，其中泰国最高 （50%） 和美国最低 （33%）。糖尿病、低白蛋白和磷升高的中度至极度瘙痒的校正比值比 （aOR） 较高，但残余尿量较低 （aOR= 24 小时尿量每增加 200 ml 0.98,95% 置信区间 [CI];0.96-1.00，P = 0.05）。极度瘙痒患者的心理和身体健康成分评分最低，其他 PRO 的负担较高，包括不宁腿和睡眠不安。总体而言，899 例患者死亡，1221 例转为 HD。中度至极度瘙痒患者死亡或 HD 转移的调整风险更高 （调整后风险比 [aHR] 1.12,95% CI 1.02-1.23，P = 0.02），复合结局的每个亚组分的点估计相似。结论： 瘙痒在 PD 中高度普遍，并与不良健康结果相关。应考虑在该人群中更好地识别和管理瘙痒。 美国肾脏病学会版权所有 © 2024...