Group B Coxsackieviruses (CVBs) consist of six serotypes, CVB1 to CVB6, which can clinically affect the heart, brain, liver, pancreas and other organs, causing myocarditis, encephalitis, myelitis, pancreatitis, hand-foot-and-mouth disease (HFMD) and other diseases, and can even lead to death. CVBs are widespread globally and highly contagious. However, there are currently no approved CVB vaccines or effective treatments. The construction and optimization of animal models will aid in the in-depth understanding of CVB infections and its pathogenesis, providing essential tools for the exploration of vaccine development and antiviral therapies. This paper reviews the latest research progress and application prospects of CVB animal models.

中文翻译：

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B 组柯萨奇病毒感染动物模型的研究进展及应用前景.


B 组柯萨奇病毒 （CVBs） 由 CVB1 到 CVB6 六种血清型组成，临床上可影响心脏、大脑、肝脏、胰腺等器官，引起心肌炎、脑炎、脊髓炎、胰腺炎、手足口病 （HFMD） 等疾病，甚至可导致死亡。CVB 在全球范围内广泛传播且具有高度传染性。然而，目前还没有批准的 CVB 疫苗或有效的治疗方法。动物模型的构建和优化将有助于深入了解 CVB 感染及其发病机制，为探索疫苗开发和抗病毒治疗提供重要工具。本文综述了CVB动物模型的最新研究进展和应用前景。