Structural insights into alterations in the substrate spectrum of serine-β-lactamase OXA-10 from Pseudomonas aeruginosa by single amino acid substitutions,Emerging Microbes & Infections

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Structural insights into alterations in the substrate spectrum of serine-β-lactamase OXA-10 from Pseudomonas aeruginosa by single amino acid substitutions
Emerging Microbes & Infections ( IF 8.4 ) Pub Date : 2024-10-22 , DOI: 10.1080/22221751.2024.2412631
Chae-eun Lee, Yoonsik Park, Hyunjae Park, Kiwoong Kwak, Hyeonmin Lee, Jiwon Yun, Donghyun Lee, Jung Hun Lee, Sang Hee Lee, Lin-Woo Kang

The extensive use of β-lactam antibiotics has led to significant resistance, primarily due to hydrolysis by β-lactamases. OXA class D β-lactamases can hydrolyze a wide range of β-lactam antibiotics...

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