Inadequate repair of the intervertebral disc (IVD) contributes to low back pain. Infiltrating immune cells into damaged tissues are critical mediators of repair, yet little is known about the identities, roles, and temporal regulation following IVD injury. By analyzing transcripts of immune cell markers, histopathologic analysis, immunofluorescence, and flow cytometry, we aimed to define the temporal cascade of infiltrating immune cells and their associations with IVD degeneration.

中文翻译：

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椎间盘急性损伤反应期间浸润免疫细胞类型和时间的性别特异性差异及其与退化的关系


椎间盘 （IVD） 修复不充分会导致腰痛。将免疫细胞浸润到受损组织中是修复的关键介质，但人们对 IVD 损伤后的身份、作用和时间调节知之甚少。通过分析免疫细胞标志物的转录物、组织病理学分析、免疫荧光和流式细胞术，我们旨在定义浸润免疫细胞的时间级联反应及其与 IVD 变性的关系。