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Association between thyroid function and osteoarthritis: a population-based cohort study.
Osteoarthritis and Cartilage ( IF 7.2 ) Pub Date : 2024-11-11 , DOI: 10.1016/j.joca.2024.10.017
Yanning Xu,Ingrid A Szilagyi,Cindy G Boer,Bahar Sedaghati-Khayat,W Edward Visser,Joyce B van Meurs,Layal Chaker

OBJECTIVES Previous genetic and animal studies indicated a causal role of thyroid hormones in osteoarthritis (OA), which has not been observed in the general population. We aimed to investigate whether thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were associated with hand, hip, or knee OA. METHODS Participants from the Rotterdam Study with baseline TSH, FT4, and joint radiographs were included. We used multivariable regression models to investigate the association of thyroid function with the prevalence, severity, incidence, and progression of OA. We conducted stratified analyses by sex, age, body mass index (BMI) and weight-bearing physical activity. RESULTS Among 9054 participants included (mean age 65 years, 56.3% women), higher FT4 concentrations were associated with an increased risk of prevalent knee OA (OR 1.04 per pmol/L, 95% CI 1.01-1.06, corresponding to an OR of 1.62 across the reference range [i.e., 14pmol/L changes] of FT4) and more severe knee OA. There was a positive association between FT4 and overall progression of knee OA (OR 1.03 per pmol/L, 1.00-1.07). No association of TSH with hand, hip, or knee OA was identified. Stratified analysis revealed an association between FT4 and prevalent knee OA among individuals with BMI≥30 kg/m2 (OR 1.05 per pmol/L, 1.01-1.08) and those with high levels of weight-bearing physical activity (OR 1.05 per pmol/L, 1.01-1.10). CONCLUSIONS Our study indicated that higher FT4 concentrations may increase the risk of knee OA. This association might be greater in individuals with extra joint loading, such as those with obesity.

中文翻译:


甲状腺功能与骨关节炎之间的关联:一项基于人群的队列研究。



目的 先前的遗传学和动物研究表明甲状腺激素在骨关节炎 (OA) 中的因果作用,这在普通人群中尚未观察到。我们旨在研究促甲状腺激素 (TSH) 和游离甲状腺素 (FT4) 是否与手、髋或膝 OA 相关。方法 包括来自鹿特丹研究的基线 TSH 、 FT4 和关节 X 光片的参与者。我们使用多变量回归模型来研究甲状腺功能与 OA 的患病率、严重程度、发生率和进展的相关性。我们按性别、年龄、体重指数 (BMI) 和负重身体活动进行了分层分析。结果在纳入的 9054 名参与者 (平均年龄 65 岁,56.3% 为女性) 中,较高的 FT4 浓度与患病性膝关节 OA 的风险增加相关 (OR 1.04/pmol/L,95% CI 1.01-1.06,对应于 FT4 的参考范围 [即 14pmol/L 变化] 的 OR 为 1.62)和更严重的膝关节 OA。FT4 与膝关节 OA 总体进展呈正相关 (OR 1.03/pmol/L,1.00-1.07)。未发现 TSH 与手、髋或膝关节 OA 的关联。分层分析显示,FT4 与 BMI≥30 kg/m2 (OR 1.05/pmol/L,1.01-1.08) 和高水平负重体力活动 (OR 1.05/pmol/L,1.01-1.10) 的个体之间是否存在相关性。结论 我们的研究表明,较高的 FT4 浓度可能会增加膝关节 OA 的风险。这种关联在关节负荷较大的个体(例如肥胖者)中可能更大。
更新日期:2024-11-11
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