Evidence-based hierarchy of pain outcome measures for osteoarthritis clinical trials and meta-analyses,Osteoarthritis and Cartilage

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Evidence-based hierarchy of pain outcome measures for osteoarthritis clinical trials and meta-analyses
Osteoarthritis and Cartilage ( IF 7.2 ) Pub Date : 2024-09-04 , DOI: 10.1016/j.joca.2024.08.013
Pakeezah Saadat ₁ , Tiago V Pereira ₂ , Rahim Lalji ₃ , Henry D Kiyomoto ₄ , Nicolas S Bodmer ₁ , Pavlos Bobos ₅ , Samir Iskander ₆ , Areti-Angeliki Veroniki ₇ , Gillian A Hawker ₈ , Alex J Sutton ₉ , Peter Jüni ₁₀ , Bruno R da Costa ₁₁

Affiliation

Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada.
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, Oxfordshire, UK.
Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland.
Department of Physiotherapy, Centro Universitário da Faculdade das Americas, São Paulo, Brazil.
School of Physical Therapy, Faculty of Health Science, Western University, London, ON, Canada.
Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada.
Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada; Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.
Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada; Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Department of Population Health Sciences, University of Leicester, Leicester, UK.
Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, Oxfordshire, UK.
Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, Oxfordshire, UK; Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.

To rank commonly used patient-reported outcome measures (PROMs) for assessing pain in osteoarthritis trials according to their assay sensitivity, defined as the ability of a PROM to distinguish an effective from a less effective intervention or placebo, proposing a hierarchy for PROM selection in trials and data-extraction in meta-analyses.

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