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Protein folding dependence on selenoprotein M contributes to steady cartilage extracellular matrix repressing ferroptosis via PERK/ATF4/CHAC1 axis
Osteoarthritis and Cartilage ( IF 7.2 ) Pub Date : 2024-10-15 , DOI: 10.1016/j.joca.2024.10.005
Yitong Zhao, Ying Zheng, Han Li, Yao Li, Ru Wang, Yongsong Cai, Haishi Zheng, Xinyu Huo, Jiajun Ren, Dongxian Guo, Rui Luo, Xinyao Wu, Jingyi Lu, Qingxin Song, Yan Zhang, Chenxing Ma, Lu Wang, Runyuan Wang, Jing Wang, Yingli He, Peng Xu, Jian Sun, Shemin Lu

Initiation of endoplasmic reticulum (ER) stress is pivotal to the advancement of osteoarthritis (OA). We aimed to explore the function of ER-resident selenoprotein M (SELM) in cartilage-forming chondrocytes, investigating how SELM participates in cartilage extracellular matrix (ECM) metabolism and ER stress modulation.

中文翻译:


蛋白质折叠对硒蛋白 M 的依赖性有助于稳定的软骨细胞外基质通过 PERK/ATF4/CHAC1 轴抑制铁死亡



内质网 (ER) 应激的启动对骨关节炎 (OA) 的进展至关重要。我们旨在探索 ER 驻留硒蛋白 M (SELM) 在软骨形成软骨细胞中的功能,研究 SELM 如何参与软骨细胞外基质 (ECM) 代谢和 ER 应激调节。
更新日期:2024-10-15
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