Arthritis notably elevates mortality risk. It remains unclear whether the cardiovascular health (CVH) metrics improves the risk of all-cause mortality in patients with all types of arthritis. This study data from the National Health and Nutrition Examination Survey to probe the link between CVH and all-cause mortality among arthritis sufferers in the United States. CVH evaluation employed the Life's Essential 8 metrics. Mortality outcomes were scrutinized using Cox proportional hazard regression models. Additionally, a restricted cubic spline analysis delineated the linear relationship between CVH and mortality. The study also delved into the singular impact of each CVH component on mortality. In the cohort of 5919 patients with arthritis, improved CVH was linked to lower all-cause mortality. Specifically, each 10-point increment in CVH score was associated with a substantial decline in all-cause mortality risk [unadjusted hazard ratio (HR): 0.77, 95% Confidence Interval (95% CI): 0.71–0.83, P < 0.001]. Adjustments for age, sex, race, and social determinants of health further refined the HR to 0.72 (95% CI: 0.67–0.79, P < 0.001). Higher versus lower CVH scores at baseline markedly reduced mortality risk, with the most substantial decrease seen in those with ideal CVH metrics (HR: 0.39, 95% CI: 0.26–0.59, P < 0.001). Similar results were not observed in patients with inflammatory arthritis, but were seen in those with osteoarthritis or degenerative arthritis, and unknown types of arthritis. Ideal CVH substantially decreases all-cause mortality risk among patients with arthritis, confirming the critical role of CVH in arthritis management. This study advocates for CVH interventions as part of comprehensive arthritis treatment plans.

中文翻译：

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骨关节炎、炎症性关节炎和未分类关节炎患者的心血管健康指标和全因死亡率：一项全国前瞻性队列研究


关节炎显著增加死亡风险。目前尚不清楚心血管健康 （CVH） 指标是否能提高所有类型关节炎患者的全因死亡风险。这项研究数据来自全国健康和营养检查调查，旨在探讨 CVH 与美国关节炎患者全因死亡率之间的联系。CVH 评估采用了 Life's Essential 8 指标。使用 Cox 比例风险回归模型仔细检查死亡率结果。此外，受限三次样条分析描绘了 CVH 与死亡率之间的线性关系。该研究还深入探讨了每个 CVH 成分对死亡率的单一影响。在 5919 名关节炎患者的队列中，CVH 的改善与全因死亡率降低有关。具体来说，CVH 评分每增加 10 分，全因死亡风险就会大幅下降 [未调整的风险比 （HR）：0.77,95% 置信区间 （95% CI）：0.71-0.83，P < 0.001]。对年龄、性别、种族和健康的社会决定因素的调整进一步将 HR 细化为 0.72 （95% CI： 0.67–0.79，P < 0.001）。基线时较高与较低的 CVH 评分显着降低了死亡风险，其中 CVH 指标理想的患者下降幅度最大 （HR： 0.39,95% CI： 0.26–0.59，P < 0.001）。在炎症性关节炎患者中未观察到类似的结果，但在骨关节炎或退行性关节炎以及未知类型关节炎患者中观察到。理想的 CVH 大大降低了关节炎患者的全因死亡风险，证实了 CVH 在关节炎管理中的关键作用。本研究提倡将 CVH 干预作为综合关节炎治疗计划的一部分。