Skeletal muscle dysfunction is the primary cause of functional limitations in osteoarthritis, associated biomarkers have the potential as targets for early disease identification, diagnosis, and prevention of osteoarthritis disability. This review aimed to identify associations between biomarkers and lower limb skeletal muscle function in individuals with osteoarthritis. A systematic literature review and meta-analysis conducted in PubMed, MEDLINE, CINAHL, EMBASE, Scopus, SPORTDiscus and Web of Science databases from inception to 8th August 2023. Two independent reviewers performed the title, abstract, full-text screening, data extraction and methodological quality assessment. A meta-analysis was undertaken based on the available data. Twenty-four studies with 4101 participants with osteoarthritis were included (females: 78%; age range; 49 to 71 years). One study reported muscle-specific biomarkers (n = 3), whilst six studies reported osteoarthritis-specific markers (n = 5). Overall, 93 biomarkers were reported, predominately characterised as inflammatory (n = 35), metabolic (n = 15), and hormones (n = 10). Muscle strength and vitamin D reported a significant association (Hedge’s g: 0.58 (Standard Error (SE): 0.27; P = 0.03), k = 3 studies). Walking speed and high-sensitivity C-reactive protein reported no significant associations (Hedge’s g: -0.02 (SE: 0.05; P = 0.73), k = 3 studies). Associations between biomarkers and lower limb skeletal muscle function in individuals with osteoarthritis was limited, the few studies exploring lower limb muscle measures were mainly secondary outcomes. Furthermore, biomarkers were largely related to overall health, with a lack of muscle specific biomarkers. As such, the mechanistic pathways through which these associations occur are less evident, and difficult to draw clear conclusions on these relationships. Registered on PROSPERO (CRD42022359405).

中文翻译：

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骨关节炎个体生物标志物与骨骼肌功能之间的关联：系统评价和荟萃分析


骨骼肌功能障碍是骨关节炎功能受限的主要原因，相关生物标志物有可能成为早期疾病识别、诊断和预防骨关节炎残疾的靶点。本综述旨在确定骨关节炎个体生物标志物与下肢骨骼肌功能之间的关联。从建库到 2023 年 8 月 8 日，在 PubMed、MEDLINE、CINAHL、EMBASE、Scopus、SPORTDiscus 和 Web of Science 数据库中进行的系统文献综述和荟萃分析。两名独立评价员进行了标题、摘要、全文筛选、资料提取和方法学质量评价。根据现有数据进行了荟萃分析。纳入了 24 项研究，涉及 4101 名骨关节炎参与者 （女性：78%;年龄范围;49 至 71 岁）。1项研究报告了肌肉特异性生物标志物（n=3），而6项研究报告了骨关节炎特异性标志物（n=5）。总体而言，报告了 93 个生物标志物，主要表征为炎症 （n = 35）、代谢 （n = 15） 和激素 （n = 10）。肌肉力量和维生素 D 报告了显着关联（Hedge's g：0.58（标准误差 （SE）：0.27;P = 0.03），k = 3 项研究）。步行速度和高敏 C 反应蛋白报告无显著关联 （Hedge's g： -0.02 （SE： 0.05;P = 0.73），k = 3 项研究）。骨关节炎个体生物标志物与下肢骨骼肌功能之间的关联有限，少数探索下肢肌肉测量的研究主要是次要结局。此外，生物标志物在很大程度上与整体健康状况相关，缺乏肌肉特异性生物标志物。 因此，这些关联发生的机制途径不太明显，并且很难对这些关系得出明确的结论。在 PROSPERO （CRD42022359405） 上注册。