Steatotic liver disease (SLD) is one of the most prevalent liver conditions globally and a leading cause of liver transplantation, yet therapeutic advances have not kept pace with its major impact on global morbidity and mortality. This underscores the critical importance of developing and refining relevant preclinical animal models. However, preclinical research has faced significant challenges, with concerns about the translational validity of animal models, as findings often fail to accurately reflect human disease. With the recent adoption of new nomenclature for SLD in humans, questions have arisen about how to integrate these changes into preclinical models. Here, we offer suggestions on how to improve preclinical models, including the incorporation of factors such as diet, alcohol, and other metabolic stressors, to better replicate the complexity of human disease. While implementing these improvements presents practical challenges, doing so is essential for enhancing the translational relevance and reproducibility of animal studies, and advancing therapeutic discoveries. Furthermore, we address the persisting inconsistency in terminology used in animal studies and propose clinically meaningful terms that can be applied consistently to preclinical research.

中文翻译：

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在脂肪性肝病的临床前研究中实现更一致的模型和共识术语


脂肪性肝病 （SLD） 是全球最普遍的肝脏疾病之一，也是肝移植的主要原因，但治疗进展并未跟上其对全球发病率和死亡率的重大影响。这强调了开发和改进相关临床前动物模型的至关重要性。然而，临床前研究面临着重大挑战，人们担心动物模型的转化有效性，因为研究结果往往无法准确反映人类疾病。随着最近在人类中采用 SLD 的新命名法，出现了如何将这些变化整合到临床前模型中的问题。在这里，我们就如何改进临床前模型提供了建议，包括纳入饮食、酒精和其他代谢应激源等因素，以更好地复制人类疾病的复杂性。虽然实施这些改进会带来实际挑战，但这样做对于提高动物研究的转化相关性和可重复性以及推进治疗发现至关重要。此外，我们解决了动物研究中使用的术语持续存在的不一致问题，并提出了具有临床意义的术语，这些术语可以一致地应用于临床前研究。