While our understanding of pain is rapidly growing, some areas of pain research are lagging behind. This article discusses two current and inter-related gaps in knowledge that are in need of addressing: first, the connections between "brain" and "body" components of pain; and second, the process of endogenous pain resolution. Historical reasons for these research gaps are discussed and solutions are outlined based on an integrative, whole person research approach. These include comprehensive mapping of the mechanosensory and nociceptive innervation of deep tissues; developing objective, non-invasive measurements to quantify the metabolic, structural and mechanical components of the peripheral tissue environment; integrating our understanding of pain pathophysiology, across whole organs and whole body, as well as across bio-psycho-social domains; and understanding the interplay of nervous system and peripheral tissue mechanisms that promote the endogenous resolution of pain and prevent its acute-to-chronic transition. Current NIH-led efforts in these areas are outlined, including several studies within the NIH HEAL (or Help End Addition Long Term) initiative and the National Center for Complementary and Integrative Health's strategic priorities in whole person research.

中文翻译：

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从综合全人的角度解决疼痛研究中的差距。


虽然我们对疼痛的理解正在迅速增长，但疼痛研究的某些领域却落后了。本文讨论了当前需要解决的两个相互关联的知识差距：首先，疼痛的“大脑”和“身体”组成部分之间的联系;第二，内源性疼痛解决的过程。讨论了这些研究差距的历史原因，并根据综合的全人研究方法概述了解决方案。这些包括深部组织的机械感觉和伤害感受神经支配的综合标测;开发客观、无创的测量来量化外周组织环境的代谢、结构和机械成分;整合我们对疼痛病理生理学的理解，跨越整个器官和全身，以及跨生物-心理-社会领域;并了解神经系统和外周组织机制的相互作用，这些机制促进疼痛的内源性消退并防止其急性到慢性转变。概述了当前 NIH 在这些领域领导的努力，包括 NIH HEAL（或帮助结束长期添加）计划内的几项研究以及国家补充与综合健康中心在全人研究方面的战略重点。