Understanding the development of chronic pain (CP) is challenging due to its multifactorial etiology. Child maltreatment (CM), encompassing various types of neglect and abuse affecting more than one-third of the population, is a critical aspect of early-life adversity with long-lasting impacts. It is increasingly recognized for its role in altering biopsychosocial processes, potentially increasing vulnerability to CP. However, the exact path connecting CM to CP is not fully elucidated, primarily attributable to limitations in prior research, including insufficient sample sizes, inadequate consideration of comprehensive mediative variables, and a lack of longitudinal data. To address these gaps, our study utilizes a large-scale dataset (n = 150,989) comprising both cross-sectional and longitudinal data, along with an extensive range of biopsychosocial variables. Our findings reveal that all types of CMs, except physical neglect, significantly increase the risk of CP, and all types of CPs, except headache, were affected by CM. Furthermore, we demonstrate that individuals with CM histories are more predisposed to comorbid CP conditions. Importantly, biopsychosocial factors are found to explain over 60% of the association between CM and CP, with psychological factors playing a key role. This study not only characterizes the relationship between CM and CP but also underscores the influence of psychosocial elements in this dynamic interplay. These findings offer important insights into the long-term impacts of CM and provide a foundation for developing targeted therapeutic and preventive strategies for CP.

中文翻译：

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儿童虐待增加了晚年慢性疼痛的风险：来自英国生物样本库队列的生物心理社会框架。


由于其多因素病因，了解慢性疼痛 （CP） 的发展具有挑战性。儿童虐待 （CM） 包括影响超过三分之一人口的各种类型的忽视和虐待，是早期生活逆境的一个重要方面，具有持久的影响。它因其在改变生物心理社会过程方面的作用而日益得到认可，这可能会增加对 CP 的脆弱性。然而，将 CM 与 CP 联系起来的确切路径尚未完全阐明，主要是由于先前研究的局限性，包括样本量不足、对综合中介变量的考虑不足以及缺乏纵向数据。为了解决这些差距，我们的研究利用了一个大规模数据集 （n = 150,989），该数据集包含横断面和纵向数据，以及广泛的生物心理社会变量。我们的研究结果表明，除身体忽视外，所有类型的 CM 都会显着增加 CP 的风险，并且除头痛外，所有类型的 CPs 都受到 CM 的影响。此外，我们证明有 CM 病史的个体更容易合并 CP 病症。重要的是，发现生物心理社会因素可以解释 CM 和 CP 之间超过 60% 的关联，其中心理因素起着关键作用。本研究不仅表征了 CM 和 CP 之间的关系，还强调了社会心理因素在这种动态相互作用中的影响。这些发现为中医的长期影响提供了重要见解，并为制定有针对性的 CP 治疗和预防策略提供了基础。