Neuropathic pain remains difficult to treat, with drug development hampered by an incomplete understanding of the pathogenesis of the condition, as well as a lack of biomarkers. The problem is compounded by the scarcity of relevant human peripheral tissues, including skin, nerves, and dorsal root ganglia. Efforts to obtain such samples are accelerating, increasing the need for standardisation across laboratories. In this white paper, we report on a consensus meeting attended by neuropathic pain experts, designed to accelerate protocol alignment and harmonization of studies involving relevant peripheral tissues. The meeting was held in London in March 2024 and attended by 28 networking partners, including industry and patient representatives. We achieved consensus on minimal recommended phenotyping, harmonised wet laboratory protocols, statistical design, reporting, and data sharing. Here, we also share a variety of relevant standard operating procedures as supplementary protocols. We envision that our recommendations will help unify human tissue research in the field and accelerate our understanding of how abnormal interactions between sensory neurons and their local peripheral environment contribute towards neuropathic pain.

中文翻译：

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协调神经性疼痛研究：外周组织研究伦敦共识会议的结果。


神经性疼痛仍然难以治疗，由于对病情发病机制的了解不完整以及缺乏生物标志物，药物开发受到阻碍。相关人类外周组织（包括皮肤、神经和背根神经节）的稀缺使问题变得更加复杂。获取此类样本的努力正在加速，这增加了实验室标准化的需求。在本白皮书中，我们报告了由神经性疼痛专家参加的共识会议，旨在加速涉及相关外周组织的研究的方案调整和协调。该会议于 2024 年 3 月在伦敦举行，包括行业和患者代表在内的 28 个网络合作伙伴出席了会议。我们在最低限度的推荐表型、统一的湿实验室方案、统计设计、报告和数据共享方面达成了共识。在这里，我们还分享了各种相关的标准操作程序作为补充协议。我们设想我们的建议将有助于统一该领域的人体组织研究，并加速我们对感觉神经元与其局部外周环境之间的异常相互作用如何导致神经性疼痛的理解。