BackgroundRecently, the importance of peri‐implant soft tissue integration quality has been recognised as an essential factor in the long‐term success of dental implant rehabilitation.AimThe aim of this study was to explore the influence of three materials commonly used in implant dentistry, namely titanium (Ti), dental adhesive resin (Re) and polyetheretherketone (PEEK), on the peri‐implant soft tissues.MethodsIn this clinical randomised comparative study, 37 bone‐level implants were placed, and experimental transmucosal healing abutments made of different materials were randomly assigned to each implant. These abutments were removed together with the surrounding soft tissues after 8 weeks. Immunohistochemical analyses were performed to determine the presence and localisation of different immune cells. In addition, clinical and radiographic data were collected and peri‐implant bone remodeling was assessed.ResultsCompared to the Ti and PEEK groups, Re abutments revealed a higher infiltration of macrophages in the connective tissue (p = 0.04) and neutrophils in the adjacent epithelium (p = 0.03). In the Re abutments, peri‐implant bone remodeling was higher compared to the other groups (p = 0.01).ConclusionThe use of resin material as a transmucosal healing abutment should be carefully considered as it was associated with a higher presence of inflammatory cells at 8 weeks post‐implantation as well as superior bone remodeling compared to PEEK and Ti.

中文翻译：

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植入物组件材料对植入物周围软组织愈合的影响：人类组织学和免疫组织化学比较研究


背景最近，种植体周围软组织整合质量的重要性已被认为是种植牙修复长期成功的重要因素。目的本研究旨在探讨种植牙中常用的 3 种材料，即钛 （Ti）、牙科胶粘剂树脂 （Re） 和聚醚醚酮 （PEEK） 对种植体周围软组织的影响。方法在这项临床随机比较研究中，放置了 37 个骨水平种植体，并将由不同材料制成的实验性经粘膜愈合基台随机分配到每个种植体。8 周后，这些基台与周围的软组织一起切除。进行免疫组织化学分析以确定不同免疫细胞的存在和定位。此外，还收集了临床和影像学数据，并评估了种植体周围骨重塑。结果与 Ti 和 PEEK 组相比，Re 基台显示结缔组织中巨噬细胞 （p = 0.04） 和邻近上皮中中性粒细胞 （p = 0.03） 的浸润较高。在 Re 基台中，与其他组相比，种植体周围骨重塑更高 （p = 0.01）。结论应仔细考虑使用树脂材料作为经粘膜愈合基台，因为与 PEEK 和 Ti 相比，它与植入后 8 周炎症细胞的存在率更高以及骨重塑性更好有关。