Chemotherapy has long been used in the clinical management of hepatocellular carcinoma (HCC), driving the development of anticancer chemotherapy drugs. Platinum complexes have attracted significant attention and have led to the creation of a series of platinum-based drugs used in diverse cancer treatments, including HCC. However, the clinical use of platinum drugs faces critical challenges due to drug resistance and side effects. Consequently, ongoing efforts have been devoted to the continuous development of new metal complexes with antitumor properties, aiming to serve as effective alternatives for HCC treatment. In this Perspective, we summarize and highlight the progress and relevant mechanisms related to new metal complexes in the treatment of HCC over the past decade. The development of metal complexes has the potential to further expand the scope of chemotherapy applications for HCC.

中文翻译：

---

金属络合物治疗肝细胞癌的研究进展


化疗长期以来一直用于肝细胞癌 （HCC） 的临床管理，推动了抗癌化疗药物的发展。铂配合物引起了极大的关注，并导致了一系列用于各种癌症治疗（包括 HCC）的铂类药物的诞生。然而，由于耐药性和副作用，铂类药物的临床使用面临严峻挑战。因此，人们一直致力于不断开发具有抗肿瘤特性的新型金属络合物，旨在成为 HCC 治疗的有效替代品。在本期展望中，我们总结并强调了过去十年中与新型金属络合物治疗 HCC 相关的进展和相关机制。金属络合物的开发有可能进一步扩大 HCC 化疗的应用范围。