Organ availability remains a persistent problem in lung transplantation. The use of organs from donors with chronic thromboembolic disease has not been described. In this report, we discuss 2 lung transplant recipients who received organs from donors with acute bilateral pulmonary embolism. All organs underwent backtable pulmonary thromboendarterectomy (PTE) prior to implantation and notably showed evidence of chronic thromboembolic disease and subacute changes in the distal vasculature. Grafts were placed with both patients on veno-arterial (VA) extra-corporeal membrane oxygenation (ECMO). Both patients had unremarkable hospital courses with graft dysfunction scores of 0 at 48 and 72 hours. At follow-up, both patients remained free of graft rejection. We highlight the utility of lungs derived from chronic thromboembolic disease as a strategy to expand the organ pool.

中文翻译：

---

利用最近患有大面积肺栓塞和慢性血栓栓塞病的肺供体进行移植。


器官可用性仍然是肺移植中一个持续存在的问题。尚未描述使用慢性血栓栓塞性疾病供体的器官。在本报告中，我们讨论了 2 例接受急性双侧肺栓塞供体器官的肺移植受者。所有器官在植入前都接受了背表肺血栓动脉内膜切除术 （PTE），并显着显示出慢性血栓栓塞性疾病和远端脉管系统亚急性变化的证据。移植物与两名患者一起接受静脉-动脉 （VA） 体外膜肺氧合 （ECMO）。两名患者的住院病程无明显异常，48 小时和 72 小时移植物功能障碍评分为 0。在随访中，两名患者均未出现移植物排斥反应。我们强调了源自慢性血栓栓塞性疾病的肺作为扩大器官库的策略的效用。