ObjectiveWe examined the risk of adverse neonatal outcomes among children born to mothers with anorexia nervosa (AN), bulimia nervosa (BN), and eating disorder not otherwise specified (EDNOS).DesignCohort study.SettingPopulation‐based using Danish national registers.PopulationWe included 1 517 839 singletons born between 1991 and 2015 in Denmark.MethodsFor each ED subtype, we compared children born to mothers with a recent (≤ 2 years before conception and during pregnancy) or past (> 2 years before conception) diagnosis, with children born to mothers who had not been diagnosed with the ED of interest before the index delivery.Main Outcome MeasuresUsing multinomial logistic regression, we estimated relative risk ratios (RRRs) and 95% confidence intervals (CIs) for gestational age, birthweight, weight‐for‐gestational age, low Apgar score, Caesarean section, congenital malformations and postpartum haemorrhage.ResultsBoth recent and past AN were associated with increased risk of low birthweight (recent: RRR = 2.36 [95% CI = 1.76–3.18]; past: 1.22 [1.04–1.43]), small‐for‐gestational age (recent: 1.52 [1.01–2.26]; past: 1.37 [1.16–1.62]), and preterm birth (recent: 1.83 [1.37–2.45]; past: 1.17 [1.00–1.36]), with more pronounced risks in recent AN. Recent (but not past) BN was associated with increased risk of low Apgar score (1.44 [1.03–2.00]). Recent (but not past) EDNOS was associated with increased risk of SGA (1.53 [1.04–2.27]).ConclusionsChildren born to mothers with EDs have an increased risk of some adverse neonatal outcomes, with more pronounced risks in recent than past EDs. These results underscore the need for improved prevention of maternal EDs and enhanced monitoring throughout pregnancy to mitigate adverse outcomes.

中文翻译：

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饮食失调母亲所生儿童的不良新生儿结局：一项基于登记的队列研究


目的我们检查了患有神经性厌食症 （AN）、神经性贪食症 （BN） 和未另行说明的进食障碍 （EDNOS） 母亲所生儿童的不良新生儿结局风险。DesignCohort 研究。设置使用丹麦国家登记册基于人口。人口我们纳入了 1991 年至 2015 年间在丹麦出生的 1 517 839 名单身人士。方法对于每种 ED 亚型，我们将最近 （≤ 受孕前 2 年和怀孕期间） 或过去 （> 受孕前 2 年） 诊断的母亲所生的孩子与在指数分娩前未被诊断出患有感兴趣的 ED 的母亲所生的孩子进行了比较。主要结局指标使用多项 logistic 回归，我们估计了胎龄、出生体重、胎龄别体重、低 Apgar 评分、剖宫产、先天性畸形和产后出血的相对风险比 （RRR） 和 95% 置信区间 （CIs）。结果近期和既往 AN 均与低出生体重风险增加相关（最近：RRR = 2.36 [95% CI = 1.76–3.18];过去：1.22 [1.04–1.43]）、小于胎龄儿（最近：1.52 [1.01–2.26];过去：1.37 [1.16–1.62]）和早产（最近：1.83 [1.37–2.45];过去：1.17 [1.00–1.36]），近期 AN 的风险更明显。近期（但不是过去）BN 与低 Apgar 评分风险增加相关 （1.44 [1.03–2.00]）。近期（但不是过去）EDNOS 与 SGA 风险增加相关 （1.53 [1.04–2.27]）。结论患有 ED 的母亲所生的孩子发生一些不良新生儿结局的风险增加，近期 ED 的风险比过去的 ED 更明显。这些结果强调需要改进孕产妇 ED 的预防和加强整个妊娠期的监测，以减少不良结局。