ObjectiveTo investigate whether serum progesterone (P4) levels on embryo transfer (ET) day correlate with the likelihood of live birth in artificial frozen–thawed transfer cycles using intramuscular progesterone.DesignRetrospective cohort study.SettingUniversity‐affiliated hospital.PopulationPatients undergoing single euploid blastocyst transfer after preimplantation genetic testing.MethodsLive birth rate (LBR) was calculated in each percentile of serum P4 to detect a threshold associated with an increased probability of LB. The association between serum P4 and pregnancy outcomes was evaluated using multivariable logistic regression analysis.Main Outcome MeasuresLBR was the primary outcome. Secondary outcomes included clinical pregnancy rate (CPR) and early pregnancy loss (EPL) rate.ResultsIn total, 761 patients were included, and the overall LBR was 55.72%. For LBR, each percentile group of serum P4 did not significantly differ. The distributions of P4 were comparable between the LB and non‐LB groups, with an average of 12.62 ± 4.05 and 12.84 ± 4.39 ng/mL, respectively. The multivariate analysis revealed that serum P4 did not affect the LBR, whereas the day of the blastocyst (D5 vs. D6: adjusted odds ratio [aOR] 2.15, 95% confidence interval [CI] 1.52–3.03) and embryo quality (good vs. viable embryo: aOR 1.88, 95% CI 1.37–2.58) were independently associated with LBR. Similarly, serum P4 was not associated with CPR and EPL rates.ConclusionsSerum P4 levels on ET day do not predict LBR in artificial cycles with intramuscular progesterone.

中文翻译：

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胚胎移植当天的血清孕酮水平不是整倍体囊胚移植冷冻解冻胚胎移植结果的可靠预测指标：一项回顾性队列研究


目的探讨胚胎移植 （ET） 日血清孕酮 （P4） 水平是否与肌内注射孕酮人工冻融转移周期中活产的可能性相关。设计回顾性队列研究。地点大学附属医院。人群植入前基因检测后接受单个整倍体囊胚移植的患者。方法计算血清 P4 每个百分位数的活产率 （LBR），以检测与 LB 概率增加相关的阈值。使用多变量 logistic 回归分析评估血清 P4 与妊娠结局之间的相关性。主要结局指标LBR 是主要结局。次要结局包括临床妊娠率 （CPR） 和早期妊娠丢失 （EPL） 率。结果共纳入 761 例患者，总体 LBR 为 55.72%。对于 LBR，血清 P4 的每个百分位组没有显著差异。LB 组和非 LB 组之间的 P4 分布相当，平均分别为 12.62 ± 4.05 和 12.84 ± 4.39 ng/mL。多变量分析显示，血清 P4 不影响 LBR，而囊胚当天 （D5 vs. D6： 调整比值比 [aOR] 2.15,95% 置信区间 [CI] 1.52-3.03） 和胚胎质量 （良好与活胚胎： aOR 1.88,95% CI 1.37-2.58） 与 LBR 独立相关。同样，血清 P4 与 CPR 和 EPL 率无关。结论ET 日血清 P4 水平不能预测肌内黄体酮人工周期中的 LBR。