A rare intermediate population of basal cells expressing luminal markers has been identified. Markers of this cell population include Nkx3.1, Pbsn, C1rb, Fgl1 and Mmp7. In these cells, termed Basal-B cells, activated JAK–STAT signalling was identified and its inhibition reduced expression of the markers characterizing these cells. Inflammation increased Basal-B cell-to-luminal cell transdifferentiation and JAK–STAT inhibition decreased this process. Deletion of PTEN increased the numbers of NKX3.1-expressing Basal-B-like cells. Thus, Basal-B cells have been identified as a crucial intermediate population within the prostate basal cell population. Moreover, JAK–STAT signalling was identified as a potential target for patients with prostate inflammation.

已经确定了一种罕见的表达管腔标志物的基底细胞中间群。该细胞群的标志物包括 Nkx3.1、Pbsn、C1rb、Fgl1 和 Mmp7。在这些细胞（称为 Basal-B 细胞）中，发现了激活的 JAK-STAT 信号传导，其抑制降低了表征这些细胞的标志物的表达。炎症增加了基础 B 细胞到管腔细胞的转分化，而 JAK-STAT 抑制减少了这一过程。PTEN 的缺失增加了表达 NKX3.1 的基础 B 样细胞的数量。因此，基底 B 细胞已被确定为前列腺基底细胞群中的关键中间细胞群。此外，JAK-STAT 信号转导被确定为前列腺炎症患者的潜在靶点。