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3-Year Survival Outcomes of Patients with Enhanced Recovery After Surgery vs. Conventional Care in Laparoscopic Distal Gastrectomy: The GISSG1901 Randomized Clinical Trial.
Annals of Surgery ( IF 7.5 ) Pub Date : 2024-12-11 , DOI: 10.1097/sla.0000000000006603 Yulong Tian,Shougen Cao,Leping Li,Wenbin Yu,Yinlu Ding,Guangyong Zhang,Lixin Jiang,Jianjun Qu,Hao Wang,Xinjian Wang,Weizheng Mao,Huanhu Zhang,Xianqun Chu,Xizeng Hui,Dongfeng Zhang,Zhaojian Niu,Changqing Jing,Haitao Jiang,Xiaodong Liu,Zequn Li,Henrik Kehlet,Yanbing Zhou,
Annals of Surgery ( IF 7.5 ) Pub Date : 2024-12-11 , DOI: 10.1097/sla.0000000000006603 Yulong Tian,Shougen Cao,Leping Li,Wenbin Yu,Yinlu Ding,Guangyong Zhang,Lixin Jiang,Jianjun Qu,Hao Wang,Xinjian Wang,Weizheng Mao,Huanhu Zhang,Xianqun Chu,Xizeng Hui,Dongfeng Zhang,Zhaojian Niu,Changqing Jing,Haitao Jiang,Xiaodong Liu,Zequn Li,Henrik Kehlet,Yanbing Zhou,
OBJECTIVES
The efficacy of enhanced recovery after surgery (ERAS) to improve the prognosis of patients who undergo laparoscopic distal gastrectomy (LDG) for gastric cancer is uncertain. This randomized study compared oncological outcomes in LDG after ERAS or conventional care.
BACKGROUND
At present, randomized controlled trials have confirmed that ERAS can improve the short-term clinical outcomes of patients undergoing LDG, but whether it improves survival has not been reported yet.
METHODS
A multicenter, randomized, controlled trial was performed to compare oncological outcomes of ERAS versus conventional care in LDG. Between April 4, 2019, and March 18, 2020, 527 patients with locally advanced lower gastric adenocarcinoma were recruited from 13 centers in China. The primary endpoints were 3-year overall survival (OS) and disease-free survival (DFS). The secondary endpoints were complications, mortality, recovery, time of receiving adjuvant chemotherapy and medical expenses.
RESULTS
The full analysis set included 186 cases in the ERAS group and 184 in conventional group, well balanced with respect to patient demographics and baseline characteristics (published before). Postoperative hospital stay and the interval before adjuvant chemotherapy were obviously shorter in the ERAS group compared to conventional group as reported previously and with lower medical expenses. Compared with the conventional group, ERAS group had fewer overall complications (21.0% vs. 30.4%, respectively; P=0.037). The median (IQR) follow-up for all cases was 42.17 (range, 3.12-48.50) months. The 3-year OS and DFS in the ERAS group and conventional group were 86.56% and 80.11% (log-rank P=0.025), 79.57% and 69.57% (log-rank P=0.027), respectively. In a subgroup analysis of stage I and II disease patients, 3-year OS and DFS were similar between the groups (P=0.901; P=0.859 for stage I and P=0.421; P=0.459 for stage II). However, in the stage III disease, the ERAS group exhibited longer 3-year OS and DFS than the conventional group (79.41% vs. 64.47% for OS, log-rank P=0.046; 70.59% vs. 53.95% for DFS, log-rank P=0.046).
CONCLUSIONS
Patients undergoing ERAS LDG had fewer overall complications, shorter hospital stay, decreased medical expenses, and improved 3-year OS and DFS rates, particularly in cases with stage III gastric cancer.
更新日期：2024-12-11
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