BACKGROUND Device-related infection (DRI) remains a cause of morbidity and mortality following durable left ventricular assist device (dLVAD) implantation. We evaluated outcomes following pump exchange (PE) for DRI following dLVAD implantation. METHODS Forty-nine patients underwent PE between 1/2007 and 12/2022 for major DRI. Outcomes included survival, incidence of subsequent DRI, and proportion of patients achieving success (freedom from DRI at 1-year following PE). RESULTS Median age was 49 years. Median time from primary implant to DRI diagnosis and from diagnosis to PE was 26 and 4.1 months, respectively. Median time to DRI recurrence was 5.8 months with 76% of patients achieving success. Success was obtained in 23/24 (96%) of patients whose time to PE from DRI diagnosis was ≤ 4 months and 14/25 (56%) if time > 4 months. CONCLUSION Most patients achieve success following PE for DRI. The risk of subsequent DRI and mortality remains high. Early (≤ 4 months) PE following DRI diagnosis increases the likelihood of success, while reducing the rate of subsequent DRI.

中文翻译：

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接受耐用左心室辅助装置的患者主要装置相关感染的泵更换。


背景 设备相关感染 （DRI） 仍然是耐用左心室辅助装置 （dLVAD） 植入后并发症和死亡率的原因。我们评估了 dLVAD 植入后 DRI 的泵更换 （PE） 后的结局。方法 49 例患者在 2007 年 1 月至 2022 年 12 月期间因主要 DRI 接受了 PE。结局包括生存率、后续 DRI 的发生率和成功的患者比例（PE 后 1 年无 DRI）。结果 中位年龄为 49 岁。从初次种植体到 DRI 诊断和从诊断到 PE 的中位时间分别为 26 个月和 4.1 个月。DRI 复发的中位时间为 5.8 个月，76% 的患者取得成功。23/24 （96%） 的患者从 DRI 诊断到 PE 的时间≤ 4 个月，如果时间 > 4 个月，则 14/25 （56%） 获得成功。结论 大多数患者在 PE 后为 DRI 取得成功。随后发生 DRI 和死亡的风险仍然很高。DRI 诊断后的早期 （≤ 4 个月） PE 会增加成功的可能性，同时降低后续 DRI 的发生率。