Antipsychotic polypharmacy remains a clinical reality, despite an increased risk of adverse events and little evidence of additional efficacy compared with antipsychotic monotherapy. In this systematic review and meta-analysis, we aimed to provide a comprehensive assessment of antipsychotic polypharmacy prevalence, trends, and correlates across mental disorders.

中文翻译：

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抗精神病药物多药治疗的患病率、相关性、耐受性相关结局和疗效相关结局：系统评价和荟萃分析


尽管与抗精神病药单药治疗相比，不良事件的风险增加且几乎没有证据表明有额外的疗效，但抗精神病药多药治疗仍然是一种临床现实。在本系统评价和荟萃分析中，我们旨在提供对抗精神病药物多药治疗患病率、趋势和精神障碍相关性的全面评估。