OBJECTIVE To develop a consensus on histologic human ovarian follicle staging nomenclature, provide guidelines for follicle density calculation, and assess changes due to fixation to enhance communication among clinicians and ovarian biology researchers in order to gain a deeper understanding of human fertility. METHODS Beginning in March 2021, the Ovarian Nomenclature Workshop's Follicle Classification Working Subgroup was organized by the Pediatric and Adolescent Gynecology program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). RESULTS The Follicle Working Subgroup recommends consolidation and expansion of the current classification systems to include six stages of normal preantral follicles, five stages of normal antral follicles, as well as categories of corpus lutea, abnormal preantral follicles, abnormal antral follicles, and other distinct follicle types. The new preantral staging added intermediate stages (primordial, transitional primordial, primary, transitional primary, secondary, multilayer ovarian follicles). The antral follicle staging includes: early pre-selection, selection, dominance, and pre-ovulatory follicles. Abnormal preantral follicles include those with an abnormal oocyte (AMF-o), granulosa cells (AMF-g), or both (AMF-og). We suggest a uniform way of calculating mean follicle density in number of follicles/mm2. CONCLUSION To establish a consensus in ovarian follicle terminology, the Ovarian Follicle Working Subgroup of the NICHD Ovarian Nomenclature Workshop standardized Follicle Staging Nomenclature and Follicle Density Calculating Systems so consistent common language can be used among ovarian biology researchers and clinicians.

中文翻译：

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人类卵巢卵泡形态的分类：NICHD 赞助的卵巢命名研讨会的建议。


目的 就组织学人类卵巢卵泡分期命名法达成共识，为卵泡密度计算提供指南，并评估固定引起的变化，以加强临床医生和卵巢生物学研究人员之间的交流，以更深入地了解人类生育能力。方法 从 2021 年 3 月开始，卵巢命名研讨会的卵泡分类工作小组由 Eunice Kennedy Shriver 国家儿童健康与人类发展研究所 （NICHD） 的儿科和青少年妇科项目组织。结果 卵泡工作小组建议整合和扩展当前的分类系统，包括正常窦前卵泡的六个阶段、正常窦卵泡的五个阶段，以及黄体、异常窦前卵泡、异常窦卵泡和其他不同卵泡类型的类别。新的鼻窦前分期增加了中间阶段（原始、过渡原始、原发、过渡原发、次级、多层卵巢卵泡）。窦卵泡分期包括：早期预选、选择、优势和排卵前卵泡。异常的窦前卵泡包括卵母细胞异常 （AMF-o）、颗粒细胞异常 （AMF-g） 或两者兼而有之 （AMF-og） 的卵泡。我们建议采用一种统一的方法来计算以卵泡数/mm 2 为单位的平均卵泡密度。结论 为了在卵巢卵泡术语方面建立共识，NICHD 卵巢命名研讨会的卵巢卵泡工作小组标准化了卵泡分期命名法和卵泡密度计算系统，以便卵巢生物学研究人员和临床医生可以使用一致的通用语言。