Epidemiological evidence suggests the presence of common risk factors for the development and prognosis of both cardio- and cerebrovascular diseases, including stroke, Alzheimer's disease, vascular dementia, heart, and peripheral vascular diseases. Accumulation of harmful blood signals may induce organotypic endothelial dysfunction affecting blood–brain barrier function and vascular health in age-related diseases. Genetic-, age-, lifestyle- or cardiovascular therapy–associated imbalance of amyloid-beta (Aβ) peptide metabolism in the brain and periphery may be the missing link between age-related neurocardiovascular diseases. Genetic polymorphisms of genes related to Aβ metabolism, lifestyle modifications, drugs used in clinical practice, and Aβ-specific treatments may modulate Aβ levels, affecting brain, vascular, and cardiac diseases. This narrative review elaborates on the effects of interventions on Aβ metabolism in the brain, cerebrospinal fluid, blood, and peripheral heart or vascular tissues. Implications for clinical applicability, gaps in knowledge, and future perspectives of Aβ as the link among age-related neurocardiovascular diseases are also discussed.

中文翻译：

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年龄相关性神经心血管疾病中的 β 淀粉样蛋白代谢


流行病学证据表明，心脑血管疾病的发生和预后存在共同的危险因素，包括中风、阿尔茨海默病、血管性痴呆、心脏和外周血管疾病。有害血液信号的积累可能会诱发器官型内皮功能障碍，从而影响年龄相关疾病的血脑屏障功能和血管健康。大脑和外周地区与遗传、年龄、生活方式或心血管治疗相关的 β 淀粉样蛋白 （Aβ） 肽代谢失衡可能是与年龄相关的神经心血管疾病之间缺失的环节。与 Aβ 代谢、生活方式改变、临床实践中使用的药物和 Aβ 特异性治疗相关的基因遗传多态性可能会调节 Aβ 水平，影响大脑、血管和心脏疾病。本叙述性综述详细阐述了干预措施对大脑、脑脊液、血液和外周心脏或血管组织中 Aβ 代谢的影响。还讨论了 Aβ 作为年龄相关神经心血管疾病之间联系的临床适用性、知识差距和未来前景的影响。