Pregnancy complicated by maternal obesity contributes to an increased cardiovascular risk in offspring, which is increasingly concerning as the rates of obesity and cardiovascular disease are higher than ever before and still growing. There has been much research in humans and preclinical animal models to understand the impact of maternal obesity on offspring health. This review summarizes what is known about the offspring cardiovascular phenotype, describing a mechanistic role for oxidative stress, metabolic inflexibility, and mitochondrial dysfunction in mediating these impairments. It also discusses the impact of secondary postnatal insults, which may reveal latent cardiovascular deficits that originated in utero. Finally, current interventional efforts and gaps of knowledge to limit the developmental origins of cardiovascular dysfunction in offspring of obese pregnancy are highlighted.

中文翻译：

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肥胖女性的怀孕和后代心血管风险增加的机制


怀孕并发孕产妇肥胖会导致后代心血管风险增加，随着肥胖和心血管疾病的发病率比以往任何时候都高并且仍在增长，这一点越来越令人担忧。已经对人类和临床前动物模型进行了大量研究，以了解孕产妇肥胖对后代健康的影响。本综述总结了对后代心血管表型的了解，描述了氧化应激、代谢不灵活和线粒体功能障碍在介导这些损伤中的机制作用。它还讨论了继发性产后损伤的影响，这可能揭示起源于子宫的潜在心血管功能障碍。最后，强调了当前限制肥胖妊娠后代心血管功能障碍发育起源的干预工作和知识差距。