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Effect of renal dialysis session on novel echocardiographic parameters of left and right ventricle in patients with end-stage renal disease
European Heart Journal ( IF 37.6 ) Pub Date : 2024-10-28 , DOI: 10.1093/eurheartj/ehae666.3251
D Afendoulis, P Sitaras, M Moutafi, P Voutas, M Ampeliotis, M Didagelos, A Kartalis

Introduction Chronic heart disease is among the leading causes of end-stage renal disease (ESR). On the other hand, patients with ESR undergoing dialysis demonstrate often subclinically impaired left and/or right ventricular function according to small studies, and higher prevalence of chronic heart disease. However, data regarding the effect of renal dialysis on novel echocardiographic parameters among renal dialysis patients remain limited.The purpose of our study, was to study the effect of renal dialysis on novel echocardiographic parameters of left and right ventricle. Methods All 50 patients (14 females) of mean age 62.9 years undergoing renal dialysis in our kidney unit regularly were included in our study. Blood pressure, heart rate and weight measurements and heart echocardiogram with measurement of LV GLS, RV GLS, RV FWS, LA ResS, E/e’ ratio, Right Ventricular Systolic pressure (PASP) and inferior vena cava (IVC) diameter, before and after renal dialysis session, were carried out. Results Mean values of body weight (79,9 vs 77,6 kg), heart rate (74,2 vs 73,5 bpm) and blood pressure (131,5/80,6 vs 123,5/76,9 mmHg) were as expected statistically significant reduced after renal dialysis (p<0,001). Values of PASP (36,1 vs 27,8 mmHg), E/e’ ratio (14 vs 12,5) and IVC diameter (1,6 vs 1,3 cm), were statistically significant reduced after renal dialysis (p<0,001). Furthermore, values of RV GLS (-19,3 vs -20,3 %), RV FWS (-21,2 vs -22,6 %) and LA ResS (29,6 vs 30,7%), were statistically significant improved after renal dialysis session (p <0,001), while LV GLS depicted a minor improvement (-17,9% vs 18,2%) not statistically significant. Conclusion In conclusion, renal dialysis session had a beneficial effect on novel echocardiographic parameters of left and right ventricle (RV GLS, RV FWS, LA ResS) due to improvement of hemodynamic parameters (blood pressure, heart rate, PASP and IVC diameter) and intravascular volume reduction. Larger clinical studies should be organized to further investigate the effect of renal dialysis on those parameters and the underlying mechanisms in the chronic setting of hemodialysis.

中文翻译:


肾透析对终末期肾病患者左心室和右心室新超声心动图参数的影响



简介 慢性心脏病是终末期肾病 (ESR) 的主要原因之一。另一方面,根据小型研究,接受透析的 ESR 患者通常表现出左心室和/或右心室功能亚临床受损,并且慢性心脏病的患病率更高。然而,关于肾透析对肾透析患者新超声心动图参数影响的数据仍然有限。我们研究的目的是研究肾透析对左心室和右心室新超声心动图参数的影响。方法 所有 50 例平均年龄 62.9 岁、定期在我们的肾脏病房接受肾透析的患者 (14 例女性) 均被纳入我们的研究。在肾透析前后,进行血压、心率和体重测量以及心脏超声心动图,并测量 LV GLS、RV GLS、RV FWS、LA ResS、E/e' 比值、右心室收缩压 (PASP) 和下腔静脉 (IVC) 直径。结果 肾透析后体重 (79,9 vs 77,6 kg)、心率 (74,2 vs 73,5 bpm) 和血压 (131,5/80,6 vs 123,5/76,9 mmHg) 的平均值如预期的那样具有统计学意义降低 (p<0,001)。肾透析后 PASP (36.1 vs 27.8 mmHg)、E/e' 比值 (14 vs 12.5) 和 IVC 直径 (1.6 vs 1.3 cm) 具有统计学意义降低 (p<0,001)。此外,RV GLS(-19,3 对 -20,3 %)、RV FWS(-21,2 对 -22,6%)和 LA ResS(29,6 对 30,7%)的值在肾透析后有统计学意义改善(p <0,001),而 LV GLS 则略有改善(-17,9% 对 18,2%),无统计学意义。 结论 总之,由于血流动力学参数 (血压、心率、PASP 和 IVC 直径) 的改善和血管内容量的减少,肾透析对左心室和右心室新的超声心动图参数 (RV GLS、RV FWS、LA ResS) 具有有益影响。应组织更大规模的临床研究,以进一步研究肾透析对这些参数的影响以及血液透析慢性情况下的潜在机制。
更新日期:2024-10-28
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