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Mapping metastatic breast cancer complexity through single-cell and spatial profiling
Nature Medicine ( IF 58.7 ) Pub Date : 2024-10-30 , DOI: 10.1038/s41591-024-03308-9


Techniques for single-cell and spatial expression profiling hold great promise for defining the complexity of metastatic microenvironments, but different methods give different representations. We profile 67 biopsies of metastatic breast cancer using up to 6 different methods, provide a systematic comparison and reveal spatial aspects of breast cancer biology across diverse clinicopathological features.

中文翻译:


通过单细胞和空间分析绘制转移性乳腺癌复杂性



单细胞和空间表达谱分析技术在定义转移性微环境的复杂性方面具有很大的前景,但不同的方法给出不同的表示。我们使用多达 67 种不同的方法对 67 例转移性乳腺癌活检进行了分析,提供了系统比较,并揭示了不同临床病理特征中乳腺癌生物学的空间方面。
更新日期:2024-10-31
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