Metastatic spread of cancer to the brain has a devastating effect on patient outcomes, yet identifying patients who will develop brain metastases is difficult in current clinical practice. We show that DNA methylation signatures from lung adenocarcinomas can accurately predict which patients are at risk of metastasis to the brain, which could transform future cancer care.

中文翻译：

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使用肿瘤 DNA 甲基化组预测癌症向大脑的转移


癌症向脑部的转移扩散对患者的预后具有破坏性影响，但在目前的临床实践中，很难识别哪些患者会发展为脑转移。我们表明，来自肺腺癌的 DNA 甲基化特征可以准确预测哪些患者有转移至大脑的风险，这可能会改变未来的癌症护理。